[Changes in activity of phospholipase A2 and its metabolic production of prostaglandins in lung tissue of asthmatic guinea pigs].
Identifieur interne : 002E17 ( Main/Exploration ); précédent : 002E16; suivant : 002E18[Changes in activity of phospholipase A2 and its metabolic production of prostaglandins in lung tissue of asthmatic guinea pigs].
Auteurs : G T Yan [République populaire de Chine]Source :
- Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases [ 1001-0939 ] ; 1992.
Descripteurs français
- KwdFr :
- 6-Cétoprostaglandine Fl alpha (métabolisme), Albumines, Animaux, Asthme (), Asthme (enzymologie), Asthme (métabolisme), Chloroquine (administration et posologie), Cochons d'Inde, Dinoprost (métabolisme), Dinoprostone (métabolisme), Mâle, Phospholipases A (métabolisme), Phospholipases A2, Poumon (), Poumon (enzymologie), Poumon (métabolisme), Prostaglandines (métabolisme).
- MESH :
- administration et posologie : Chloroquine.
- enzymologie : Asthme, Poumon.
- métabolisme : 6-Cétoprostaglandine Fl alpha, Asthme, Dinoprost, Dinoprostone, Phospholipases A, Poumon, Prostaglandines.
- Albumines, Animaux, Asthme, Cochons d'Inde, Mâle, Phospholipases A2, Poumon.
English descriptors
- KwdEn :
- 6-Ketoprostaglandin F1 alpha (metabolism), Albumins, Animals, Asthma (chemically induced), Asthma (enzymology), Asthma (metabolism), Chloroquine (administration & dosage), Dinoprost (metabolism), Dinoprostone (metabolism), Guinea Pigs, Lung (drug effects), Lung (enzymology), Lung (metabolism), Male, Phospholipases A (metabolism), Phospholipases A2, Prostaglandins (metabolism).
- MESH :
- chemical , administration & dosage : Chloroquine.
- chemical , metabolism : 6-Ketoprostaglandin F1 alpha, Dinoprost, Dinoprostone, Phospholipases A, Prostaglandins.
- chemical : Albumins, Phospholipases A2.
- chemically induced : Asthma.
- drug effects : Lung.
- enzymology : Asthma, Lung.
- metabolism : Asthma, Lung.
- Animals, Guinea Pigs, Male.
Abstract
The activity of phospholipase A2 and its metabolic production-prostaglandins were examined in lung tissue of allergic asthmatic guinea pigs. The results shows that the activity of phospholipase A2 after three days of asthma attack was raised 54.19% than that of control group (P < 0.01), and decreased 69.27% when protected with chloroquine before asthma, and decreased 65.98% when only given chloroquine as a control; the ratio of those prostaglandins was resumed to control group when previously given chloroquine in asthma and normal guinea pigs. These results suggest that the activity of phospholipase A2 and changes of prostaglandins in lung tissue were related to allergic asthma of guinea pigs, the increase of TXB2 or PGF2 alpha and decrease of PGE2 or 6-Keto-PGF2 alpha in lung tissue after three days of asthma attack may have a correlation with allergic asthma in guinea pigs.
PubMed: 1394600
Affiliations:
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Le document en format XML
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wicri:level="3"><nlm:affiliation>Laboratory of Truma Center, 304 Hospital of PLA, Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:orgArea>Laboratory of Truma Center, 304 Hospital of PLA</wicri:orgArea></affiliation></author></analytic><series><title level="j">Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases</title><idno type="ISSN">1001-0939</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>6-Ketoprostaglandin F1 alpha (metabolism)</term><term>Albumins</term><term>Animals</term><term>Asthma (chemically induced)</term><term>Asthma (enzymology)</term><term>Asthma (metabolism)</term><term>Chloroquine (administration & dosage)</term><term>Dinoprost (metabolism)</term><term>Dinoprostone (metabolism)</term><term>Guinea Pigs</term><term>Lung (drug effects)</term><term>Lung (enzymology)</term><term>Lung (metabolism)</term><term>Male</term><term>Phospholipases A (metabolism)</term><term>Phospholipases A2</term><term>Prostaglandins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>6-Cétoprostaglandine Fl alpha (métabolisme)</term><term>Albumines</term><term>Animaux</term><term>Asthme ()</term><term>Asthme (enzymologie)</term><term>Asthme (métabolisme)</term><term>Chloroquine (administration et posologie)</term><term>Cochons d'Inde</term><term>Dinoprost (métabolisme)</term><term>Dinoprostone (métabolisme)</term><term>Mâle</term><term>Phospholipases A (métabolisme)</term><term>Phospholipases A2</term><term>Poumon ()</term><term>Poumon (enzymologie)</term><term>Poumon (métabolisme)</term><term>Prostaglandines (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Chloroquine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>6-Ketoprostaglandin F1 alpha</term><term>Dinoprost</term><term>Dinoprostone</term><term>Phospholipases A</term><term>Prostaglandins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Albumins</term><term>Phospholipases A2</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Asthma</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Asthme</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Asthma</term><term>Lung</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Asthma</term><term>Lung</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>6-Cétoprostaglandine Fl alpha</term><term>Asthme</term><term>Dinoprost</term><term>Dinoprostone</term><term>Phospholipases A</term><term>Poumon</term><term>Prostaglandines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Guinea Pigs</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Albumines</term><term>Animaux</term><term>Asthme</term><term>Cochons d'Inde</term><term>Mâle</term><term>Phospholipases A2</term><term>Poumon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The activity of phospholipase A2 and its metabolic production-prostaglandins were examined in lung tissue of allergic asthmatic guinea pigs. The results shows that the activity of phospholipase A2 after three days of asthma attack was raised 54.19% than that of control group (P < 0.01), and decreased 69.27% when protected with chloroquine before asthma, and decreased 65.98% when only given chloroquine as a control; the ratio of those prostaglandins was resumed to control group when previously given chloroquine in asthma and normal guinea pigs. These results suggest that the activity of phospholipase A2 and changes of prostaglandins in lung tissue were related to allergic asthma of guinea pigs, the increase of TXB2 or PGF2 alpha and decrease of PGE2 or 6-Keto-PGF2 alpha in lung tissue after three days of asthma attack may have a correlation with allergic asthma in guinea pigs.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Yan, G T" sort="Yan, G T" uniqKey="Yan G" first="G T" last="Yan">G T Yan</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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